Nearly 93 percent of people with moderate to severe atopic dermatitis achieved long-term symptom relief in a six-year trial evaluating tralokinumab-ldrm (Adbry). Among the 1,600-plus participants, 92.9 percent saw a 75 percent or greater reduction in eczema severity. Additionally, nearly 67 percent of participants achieved clear or almost-clear skin. Researchers found the drug was generally safe, and there were no new safety concerns.

Approved by the U.S. Food and Drug Administration (FDA) in 2021, tralokinumab-ldrm is a biologic treatment. It works by targeting interleukin (IL)-13, a key protein in the immune system’s inflammatory response. In people with eczema, IL-13 contributes to symptoms such as skin inflammation and itching. By blocking IL-13, the drug helps reduce inflammation and improve skin health over time.

Biologics: A New Frontier in Eczema Treatment

In recent years, biologics such as tralokinumab-ldrm and dupilumab (Dupixent) have emerged as effective treatments for eczema. Traditional treatments, such as corticosteroids and calcineurin inhibitors, address symptoms at the surface. Biologics, in contrast, target the underlying immune pathways — specifically interleukins like IL-13 and IL-4 — which are central to eczema’s inflammatory processes.

Studies have shown biologics to be effective and generally safe. They can have side effects, including injection site reactions and, less commonly, eye inflammation such as conjunctivitis. They are administered via injection, which can be done at a health care provider’s office or at home for convenience. However, this might pose a challenge for people who are uncomfortable with needles.

If you live with eczema and your current treatment regimen isn’t working, consider speaking to your health care provider. They may recommend other treatments, including biologics, that may better meet your treatment goals.

To biologic or not to biologic? Read about one MyEczemaTeam member’s experiences with this type of eczema treatment.

Find Your Team

On MyEczemaTeam, the social network for people living with eczema and their loved ones, more than 54,000 members come together to ask questions, give advice, and share their stories with others who understand life with eczema.

What are your experiences managing eczema? Have you tried biologic treatments? Share your tips and experiences in a comment below, start a conversation on your Activities page, or connect with like-minded members in Groups.